16 October 2018

By A/Prof Miranda Xhilaga - PCFA Research Team

Does Androgen Deprivation Therapy (ADT) increase the dementia risk?

More than half of men diagnosed with prostate cancer may receive ADT treatment. This treatment is efficient in decreasing male hormone levels which in turn slows tumour growth. There are established side effects of ADT but the impact of ADT on the brain function has not been established. What we do know is that male hormones (androgens) play a critical role in neuron maintenance and growth. Hence, decreasing androgen levels for extended periods of time could have a major impact on the normal function of the brain.

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